Tau Becomes a More Favorable Substrate for GSK-3 When It Is Prephosphorylated by PKA in Rat Brain

When IT Becomes a Profession

To most of the hundred millions of computer-users around the world, the inner workings of a computer are an utter mystery. Opening the box holds as much attraction as lifting the hood of a modern car. Users expect Information Technology professionals to help them with their needs for designing, locating, retrieving, using, configuring, programming, maintaining, and understanding computers, netw...

Introduction: When More Becomes Less

When becomes more in fact less?

The principles ‘in dubio abstine’ and ‘primum non nocere’ are as least as old as the language they are written in, and have been made very concrete in criticisms on iatrogenesis, medicalization, polypharmacy and polypragmasy. Clinical decision analysis [1], health technology assessment, and critical appraisal of clinical evidence [2] have provided useful methods to translate these principles in...

Electrochemical failure of the brain cortex is more deleterious when it is accompanied by low perfusion.

BACKGROUND AND PURPOSE Clinical and experimental evidence suggests that spreading depolarization facilitates neuronal injury when its duration exceeds a certain time point, termed commitment point. We here investigated whether this commitment point is shifted to an earlier period, when spreading depolarization is accompanied by a perfusion deficit. METHODS Electrophysiological and cerebral bl...

Translation and Ideology: When Faithfulness Becomes a Luxury in Translation

Every discourse, written or oral, is the conveyer of some hidden agenda of the producer, most importantly in such genres of speech as journalism, politics, propaganda, and advertisements. Given the role of translation in discourse, a difference exists between when the translator carries the ideological values of the elite in contrast with one with patriotic preferences. In this study a comparis...